Inactivated vaccine to prevent neonatal calf diarrhea


One dose of the vaccine (3 ml) contains:

Active substance:

Bovine rotavirus strain TM-91, serotype G6P1 (inactivated)       

2/3 dose of vaccine inducing ≥ 6,0 log2 (VNT), *

Bovine coronavirus strain C-197 (inactivated)          

2/3 dose of vaccine inducing ≥ 5,0 log2 (HIT) **

Escherichia coli strain EC/17 (inactivated) expressing F5 (K99) Adhesin

2/3 dose of vaccine inducing ≥ 44,8 % of inhibition (ELISA)***

* VNT – virus neutralisation test

**HIT –          hemagglutination inhibition test

***ELISA –   Enzyme-linked immunosorbent assay
target species Cattle (pregnant cows and heifers)

For active immunization of pregnant cows and heifers to provide calves with passive immunity targeted at reduction of mortality, incidence and severity of diarrhoea caused by bovine rotavirus, coronavirus and enteropathogenic E. coli F5 (K99) and reduction of rotavirus and coronavirus shedding by infected calves.

Onset of immunity: Passive immunity starts with colostrum feeding.
contra-indications None.
dosage and route of administration

For intramuscular use.

One dose: 3 ml
recommended vaccination scheme

One injection in the course of each pregnancy between the week 12 – 3 before calving is expected.


Feeding of colostrum

The protection of calves depends on adequate ingestion of colostrum from vaccinated cows. Measures should be taken to ensure that calves receive sufficient amounts of colostrum within the first few days of life. It is important that all calves receive sufficient amounts of colostrum within the first six hours after calving. The highest content of antibodies in the colostrum is reached 72 hours after parturition, however absorption of antibodies in the gut of calves is highest within the first 6 – 8 hours after parturition. In the dairy herd, it is recommended that colostrum/milk from the first 6 – 8 milkings of vaccinated mothers is collected and pooled. During the first two weeks of life, the calves must be fed with 2,5 – 3 liters of this pooled colostrum/milk per day.

To achieve optimum results and to reduce infection pressure on the farm, a whole herd cow vaccination policy should be adopted and all newborn calves should be fed with the pooled colostrum.
undiserable effects Occasionally a swelling 5-7 cm in diameter may be observed at the site of injection. Typically, such swelling resolves within 14 days.
withdrawal period Zero days
size of package 15 ml (5 doses), 90 ml (30 doses), 450 ml (150 doses)

Shelf-life of the veterinary medicinal product as packaged for sale: 36 months

Shelf-life after first opening the immediate packaging: 10 hours or discard.
storage conditions

Store in a refrigerator (2°C – 8°C).

Protect from frost. Protect from light.
country of MA Slovak republic, Czech republic, Russia, Belarus, Egypt, UAE, Bulgaria, New Zealand

Specific References

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